Pulatova M K, Filatov D E, Sharygin V L, Gorbacheva L B, Gudtsova K V, Kuropteva Z V, Zhumabaeva T T, Shamaev V I, Korman D B
Izv Akad Nauk SSSR Biol. 1990 Sep-Oct(5):737-48.
Ribonucleotide reductase activity (RRA) has been studied in various tumors and spleens of tumor-bearing animals using EPR technique and biochemical methods. The effect of a number of biologically active compounds on RRA has also been studied. RRA in tumor and spleen increases during tumor growth. Inhibitory effect of irradiation, hydroxyurea, nitrosomethylurea and activatory effect of 5-nitrofurans and nitroimidazole derivatives on RRA has been observed. Regulatory factors of RRA and DNA synthesis in vivo have been discussed.
利用电子顺磁共振技术（EPR）和生化方法，已对多种肿瘤及荷瘤动物脾脏中的核糖核苷酸还原酶活性（RRA）进行了研究。还研究了多种生物活性化合物对RRA的影响。肿瘤生长过程中，肿瘤及脾脏中的RRA会增加。已观察到辐射、羟基脲、亚硝基甲基脲对RRA的抑制作用以及5-硝基呋喃和硝基咪唑衍生物对RRA的激活作用。还讨论了体内RRA和DNA合成的调节因子。
