一例促甲状腺激素（TSH）分泌瘤合并周期性麻痹。

A case of thyrotropin (TSH)-secreting tumor complicated by periodic paralysis.

作者信息

Kiso Y, Yoshida K, Kaise K, Kaise N, Masuda T, Ando N, Kameyama M, Yamamoto M, Sakurada T, Yoshinaga K

机构信息

Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai.

出版信息

Jpn J Med. 1990 Jul-Aug;29(4):399-404. doi: 10.2169/internalmedicine1962.29.399.

DOI:10.2169/internalmedicine1962.29.399

PMID:2177117

Abstract

A 27-year-old man had symptoms of hyperthyroidism and periodic paralysis. While hyperthyroid, his serum thyrotropin (TSH) level was inappropriately elevated at 6.4 microU/ml. The serum alpha subunit level was also elevated. MR imaging revealed a pituitary tumor and transsphenoidal adenomectomy was performed. Immunocytochemistry with an antibody directed against the beta-subunit of TSH revealed a TSH-secreting tumor. This is the first case of hyperthyroidism due to a TSH-secreting pituitary tumor complicated by periodic paralysis. This association indicates that thyrotoxicosis may induce paralysis in susceptible persons by a mechanism which is not autoimmune.

摘要

一名27岁男性出现甲状腺功能亢进和周期性麻痹症状。甲状腺功能亢进时，其血清促甲状腺激素（TSH）水平异常升高至6.4微单位/毫升。血清α亚基水平也升高。磁共振成像显示垂体肿瘤，并进行了经蝶窦腺瘤切除术。用抗TSHβ亚基抗体进行免疫细胞化学检查发现了分泌TSH的肿瘤。这是首例因分泌TSH的垂体肿瘤并发周期性麻痹导致的甲状腺功能亢进病例。这种关联表明，甲状腺毒症可能通过一种非自身免疫机制在易感人群中诱发麻痹。