Meinders Arend-Jan, Bosch Frank H, Meinders Arend E
Antonius Ziekenhuis, Nieuwegein, Afd. Interne Geneeskunde en Intensive Care, the Netherlands.
Ned Tijdschr Geneeskd. 2011;155(18):A3526.
A negative water and sodium balance develops during the first hours to days after reaching a high altitude. The fluid and sodium balance does not alter in cases of altitude sickness, or may even become positive. This is attributed to a decreased diuresis and natriuresis in those who develop altitude sickness, while their fluid intake is no different to that of people who do not suffer from altitude sickness. This is a consequence of stimulation of the renin-angiotensin-aldosterone system (RAAS) and an increased secretion of antidiuretic hormone (ADH) combined with a higher than normal sympathetic activity. Therefore there is no argument for an increased fluid intake for the prevention of altitude illness. In theory this might even be harmful.
到达高海拔地区后的最初数小时至数天内会出现水钠负平衡。在高原病患者中,液体和钠平衡并无变化,甚至可能变为正平衡。这归因于患高原病者的利尿和排钠减少,而他们的液体摄入量与未患高原病者并无差异。这是肾素 - 血管紧张素 - 醛固酮系统(RAAS)受刺激、抗利尿激素(ADH)分泌增加以及交感神经活动高于正常水平共同作用的结果。因此,没有理由为预防高原病而增加液体摄入量。从理论上讲,这甚至可能有害。