黄花倒水莲鲜花对双氯芬酸钠诱导的大鼠肝毒性的保护作用。
Hepatoprotective effect of Woodfordia fruticosa Kurz flowers on diclofenac sodium induced liver toxicity in rats.
机构信息
Phytochemical, Pharmacological and Microbiological Laboratory, Department of Biosciences, Saurashtra University, Rajkot-360 005, Gujarat, India.
出版信息
Asian Pac J Trop Med. 2011 May;4(5):342-6. doi: 10.1016/S1995-7645(11)60100-4. Epub 2011 Jun 22.
OBJECTIVE
To evaluate the protective effect of Woodfordia fruticosa Kurz flowers against experimentally induced liver toxicity in rats.
METHODS
Two different doses of methanol extract of Woodfordia fruticosa (WFM) were evaluated for the hepatoprotective activity against diclofenac sodium induced hepatotoxicity in rats. Various biochemical parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), blood urea nitrogen (BUN) from serum; total protein (TP), glutathione (GSH) levels, catalase (CAT) and glutathione peroxidase (GPx) activities from liver were studied; histopathologic changes of liver were also evaluated.
RESULTS
WFM effectively reduced the elevated levels of serum ALT, AST, ALP and BUN, enhanced the reduced TP, ALB and hepatic GSH, CAT, GPx activity. The histopathological analysis suggested that WFM decreased the degree of liver fibrosis induced by diclofenac.
CONCLUSIONS
This study demonstrates the hepatoprotective activity of WFM and thus scientifically support the use of this plant in traditional medicine for the treatment of liver disorders.
目的
评价榆叶梅花对实验性肝毒性的保护作用。
方法
评价榆叶梅花甲醇提取物（WFM）对双氯芬酸钠诱导的大鼠肝毒性的保肝活性。研究了血清中天冬氨酸氨基转移酶（ALT）、丙氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、总蛋白（TP）、白蛋白（ALB）、血尿素氮（BUN）等生化参数；研究了肝组织中的总蛋白（TP）、谷胱甘肽（GSH）水平、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）活性；还评价了肝的组织病理学变化。
结果
WFM 能有效降低血清 ALT、AST、ALP 和 BUN 的升高水平，提高降低的 TP、ALB 和肝 GSH、CAT、GPx 活性。组织病理学分析表明，WFM 可降低双氯芬酸钠诱导的肝纤维化程度。
结论
本研究表明榆叶梅花具有保肝活性，从而从科学上支持了该植物在传统医学中用于治疗肝脏疾病的用途。
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