Otten T F
Probl Tuberk. 1990(9):54-7.
Rapidly growing M. fortuitum bring about such conditions in man, like mycobacterioses. Management of patients presents a problem since potentially pathogenic mycobacteria are highly resistant to most antituberculous drugs. To find effective antibacterial drugs for the treatment of human patients, the definition of sensitivity of M. fortuitum to broad--spectrum antibiotics by agar disk-diffusion method on Soton's medium was carried out. Sensitivity of 53 strains of mycobacteria to 13 drugs was investigated. It was demonstrated that the aminoglycoside group (gentamicin, kanamycin and monomycin inhibiting the growth of 96, 98 and 76% % of the strains, respectively) had been the most active. Tetracycline, ristomycin and erythromycin actively affected 35-15% of the tested strains. The agar disk-diffusion method is easy to handle and use in laboratory conditions.
快速生长的偶然分枝杆菌会在人体内引发类似分枝杆菌病的情况。由于潜在致病性分枝杆菌对大多数抗结核药物具有高度抗性，因此患者的治疗成为一个问题。为了找到治疗人类患者的有效抗菌药物，采用琼脂纸片扩散法在索顿培养基上对偶然分枝杆菌对广谱抗生素的敏感性进行了测定。研究了53株分枝杆菌对13种药物的敏感性。结果表明，氨基糖苷类药物（庆大霉素、卡那霉素和单霉素分别抑制96%、98%和76%的菌株生长）活性最强。四环素、瑞斯托菌素和红霉素对35% - 15%的受试菌株有积极影响。琼脂纸片扩散法在实验室条件下易于操作和使用。
