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在钠钾ATP酶适应性刺激过程中大鼠盲肠黏膜中环鸟苷酸水平降低。

Decreased cyclic GMP levels in rat cecum mucosa during adaptive stimulation of Na-K-ATPase.

作者信息

Grezer R, Loeschke K

出版信息

Experientia. 1979 Feb 15;35(2):197-9. doi: 10.1007/BF01920612.

DOI:10.1007/BF01920612
PMID:217720
Abstract

In rat cecal mucosa, Na-K-ATPase specific activity and sodium and fluid absorption were increased by giving polyethylene glycol administration with the drinking water. Whereas cyclic AMP levels were unchanged, cyclic GMP was reduced by about 50%. This finding suggests a regulatory role of cyclic GMP in intestinal sodium and fluid absorption.

摘要

在大鼠盲肠黏膜中，通过在饮用水中给予聚乙二醇，钠钾ATP酶的比活性以及钠和液体的吸收增加。虽然环磷酸腺苷水平未变，但环磷酸鸟苷减少了约50%。这一发现表明环磷酸鸟苷在肠道钠和液体吸收中具有调节作用。

相似文献

1
Decreased cyclic GMP levels in rat cecum mucosa during adaptive stimulation of Na-K-ATPase.在钠钾ATP酶适应性刺激过程中大鼠盲肠黏膜中环鸟苷酸水平降低。
Experientia. 1979 Feb 15;35(2):197-9. doi: 10.1007/BF01920612.
2
Evidence against cyclic GMP acting as a direct modulator of active sodium absorption in rat cecum.关于环鸟苷酸并非大鼠盲肠主动钠吸收直接调节因子的证据。
Experientia. 1981 Feb 15;37(2):123-5. doi: 10.1007/BF01963183.
3
[Intestinal adaptation of electrolyte and water resorption].
Fortschr Med. 1975 Nov 13;93(32):1613-5.
4
Induction of Na-K-ATPase in plasma membranes to rat cecum mucosa by diet: time course and kinetics.饮食对大鼠盲肠黏膜质膜中钠钾ATP酶的诱导作用：时间进程和动力学
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Effect of diphenolic laxatives on Na+-K+-activated ATPase and cyclic nucleotide content of rat colon mucosa in vivo.
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Glutamate modulates sodium-potassium-ATPase through cyclic GMP and cyclic GMP-dependent protein kinase in rat striatum.谷氨酸通过环磷酸鸟苷和环磷酸鸟苷依赖性蛋白激酶调节大鼠纹状体中的钠钾ATP酶。
Cell Biochem Funct. 2005 Mar-Apr;23(2):115-23. doi: 10.1002/cbf.1217.
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Stimulation of sodium transport and Na+-K+-ATPase activity in the hypertrophying rat cecum.
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Effect of dioctyl sodium sulfosuccinate on cyclic AMP and prostaglandin E2 contents, and Na,K-ATPase, adenylate cyclase and phosphodiesterase activities in rat intestine.
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Age-related changes in cyclic GMP and PKG-stimulated cerebellar Na,K-ATPase activity.环磷酸鸟苷（cGMP）和蛋白激酶G（PKG）刺激的小脑钠钾ATP酶活性的年龄相关变化。
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引用本文的文献

1
Inhibition by loperamide of deoxycholic acid induced intestinal secretion.洛哌丁胺对脱氧胆酸诱导的肠道分泌的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Mar;325(3):286-9. doi: 10.1007/BF00495957.
2
Loperamide reduces the intestinal secretion but not the mucosal cAMP accumulation induced by choleratoxin.洛哌丁胺可减少肠道分泌，但不影响霍乱毒素诱导的黏膜环磷酸腺苷（cAMP）积累。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Sep;317(2):178-9. doi: 10.1007/BF00500077.
3
Evidence against cyclic GMP acting as a direct modulator of active sodium absorption in rat cecum.

本文引用的文献

1
ION transport by mammalian small intestine.哺乳动物小肠的离子转运
Annu Rev Physiol. 1974;36:51-91. doi: 10.1146/annurev.ph.36.030174.000411.
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关于环鸟苷酸并非大鼠盲肠主动钠吸收直接调节因子的证据。
Experientia. 1981 Feb 15;37(2):123-5. doi: 10.1007/BF01963183.
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Effect of diphenolic laxatives on Na+-K+-activated ATPase and cyclic nucleotide content of rat colon mucosa in vivo.
Naunyn Schmiedebergs Arch Pharmacol. 1980 Sep;313(3):249-55. doi: 10.1007/BF00505741.
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Adaptation of electrolyte transport in rat large intestine after proximal resection. II. Colon after 50% jejunoilectomy combined with cecectomy.大鼠近端切除术后大肠电解质转运的适应性。II. 50%空肠回肠切除术联合盲肠切除术后的结肠。
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Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides.环核苷酸的放射免疫测定。I. 抗体及碘化环核苷酸的制备。
J Biol Chem. 1972 Feb 25;247(4):1106-13.
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Stimulation of sodium transport and Na+-K+-ATPase activity in the hypertrophying rat cecum.
Pflugers Arch. 1974;346(3):233-49. doi: 10.1007/BF00595710.
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Effects of cholera toxin on cellular and paracellular sodium fluxes in rabbit ileum.
Biochim Biophys Acta. 1976 Oct 5;448(2):352-67. doi: 10.1016/0005-2736(76)90248-0.
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Nucleic acid and protein content of rat cecum mucosa in dietary adaptation-growth by cellular hyperplasia.
Pflugers Arch. 1977 Nov 25;372(1):91-4. doi: 10.1007/BF00582211.
10
Adenylate and guanylate cyclase activities and cellular differentiation in rat small intestine.大鼠小肠中的腺苷酸环化酶和鸟苷酸环化酶活性与细胞分化
Gastroenterology. 1975 Aug;69(2):470-8.