Gorokhovatskiĭ Iu I, Kurapeev I S, Efremenkov E A, Novikov V K
Vestn Khir Im I I Grek. 1990 Aug;145(8):96-9.
The authors have shown that the suppression of the excretory function of the kidneys during the period of artificial circulation is considerably dependent on the concentration of vasopressin in blood and the associated spasm of renal vessels. The use of morphine as the main medicine for general anesthesia with the dose of 3 mg/kg as compared with the dose 2 mg/kg, gives less level of vasopressin in blood and thus reduces symptoms of antidiuresis in response to the action of strong stressogenic factors.
作者已经表明，在人工循环期间肾脏排泄功能的抑制在很大程度上取决于血液中血管加压素的浓度以及相关的肾血管痉挛。与2mg/kg的剂量相比，使用吗啡作为全身麻醉的主要药物，剂量为3mg/kg时，血液中血管加压素的水平较低，从而减轻了在强烈应激源作用下的抗利尿症状。
