慢性曲米帕明治疗对大鼠脑内生物胺代谢以及多巴胺D2、5-羟色胺2和色胺结合位点的影响。
The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain.
作者信息
Juorio A V, Li X M, Boulton A A
机构信息
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
出版信息
Gen Pharmacol. 1990;21(5):759-62. doi: 10.1016/0306-3623(90)91030-u.
PMID:2177438
Abstract
- Two week chronic administration of trimipramine increased the brain concentration and metabolism of dopamine and 5-hydroxytryptamine. 2. The treatment also produced a reduction in dopamine D2 and 5-hydroxytryptamine 5-HT2 receptors but no change in tryptamine binding was observed. 3. These findings suggest that trimipramine induces adaptive changes in dopamine and 5-hydroxytryptamine neurotransmission.
摘要
- 丙咪嗪两周的慢性给药增加了多巴胺和5-羟色胺的脑内浓度及代谢。2. 该治疗还使多巴胺D2和5-羟色胺5-HT2受体减少，但未观察到色胺结合的变化。3. 这些发现表明丙咪嗪诱导了多巴胺和5-羟色胺神经传递的适应性变化。
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