Sugimoto Hisashi, Ito Makoto, Yoshida Shinya, Hatano Miyako, Yoshizaki Tomokazu
Department of Otolaryngology-Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Ann Otol Rhinol Laryngol. 2011 Jun;120(6):372-6. doi: 10.1177/000348941112000604.
This study evaluated the efficacy of concurrent superselective intra-arterial chemotherapy and radiotherapy without surgery for late-stage squamous cell carcinoma of the temporal bone, which typically has a poor prognosis.
The subjects were 5 patients treated at our hospital between 2007 and 2010 for primary cancer of the temporal bone. One patient had a stage T3 tumor, and 4 patients had T4 tumors, according to the Pittsburgh staging system. All patients received irradiation with a conventional once-daily fraction of 2 Gy, and the total dose ranged from 60 to 66 Gy. Intra-arterial cisplatin via transfemoral catheterization and intravenous sodium thiosulfate were administered. The contribution of each vessel in supplying blood to the primary tumor was determined by real-time computed tomographic angiography.
Three patients obtained a complete response. The same 3 patients remain alive without local recurrence (mean survival, 28 months), 1 patient died of distant metastasis without local recurrence after 19 months, and 1 patient remains alive with local recurrence.
Although the small number of patients prevents comparisons with other treatments, the present study obtained good results. This may become an effective treatment for patients with late-stage squamous cell carcinoma of the temporal bone.
本研究评估了同期超选择性动脉内化疗与放疗而非手术治疗晚期颞骨鳞状细胞癌的疗效，这类癌症通常预后较差。
研究对象为2007年至2010年间在我院接受颞骨原发性癌症治疗的5例患者。根据匹兹堡分期系统，1例患者为T3期肿瘤，4例患者为T4期肿瘤。所有患者均接受常规每日一次、每次2 Gy的照射，总剂量为60至66 Gy。通过经股动脉插管给予动脉内顺铂和静脉注射硫代硫酸钠。通过实时计算机断层血管造影确定各血管对原发性肿瘤的供血贡献。
3例患者获得完全缓解。这3例患者仍存活且无局部复发（平均生存期28个月），1例患者在19个月后死于远处转移而无局部复发，1例患者存活但有局部复发。
尽管患者数量较少，无法与其他治疗方法进行比较，但本研究取得了良好的结果。这可能成为晚期颞骨鳞状细胞癌患者的一种有效治疗方法。
