Faculty of Pharmacy, Department of Pharmaceutical Technology, Panestimiopolis Zografou 15771, University of Athens, Athens, Greece.
J Liposome Res. 2012 Mar;22(1):55-61. doi: 10.3109/08982104.2011.590142. Epub 2011 Jul 20.
Classical Newtonian Physics and Euclidean Geometry are currently used to describe biological phenomena and the processes of drug formulation, which are characterized by homogeneity and linearity. On the other hand, at the mesoscopic level, the principles and the laws of physics are quite different from the Classical Newtonian Physics and Euclidean approach especially at nanoscale dimension. The investigation of the aggregation process of liposomes is of paramount importance due to their applications in pharmaceutical nanotechnology as drug delivery systems and as membrane models, in biosciences. The physical stability and the aggregation process of colloidal systems as well as the surface phenomena are described using the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. The elucidation of the dimensionality of liposome aggregates obeys the fractal approach because the aggregation phenomena are irreversible. This approach can be correlated with the extended DLVO theory, which includes the hydration energy, too.
经典牛顿物理学和欧几里得几何目前被用于描述生物现象和药物制剂过程，这些现象的特点是均匀性和线性。另一方面，在介观尺度上，物理原理和规律与经典牛顿物理学和欧几里得方法有很大的不同，特别是在纳米尺度上。由于脂质体在药物纳米技术中的应用，如作为药物传递系统和作为膜模型，因此研究脂质体的聚集过程至关重要。胶体系统的物理稳定性和聚集过程以及表面现象都可以用德热那-朗道-范韦尔比克（DLVO）理论来描述。由于聚集现象是不可逆的，因此脂质体聚集体的维度可以用分形方法来阐明。这种方法可以与扩展的 DLVO 理论相关联，该理论也包括水合能。
