婴儿指纤维瘤病中的SH丰富体——巯基分布的组织化学研究
SH abundant body in infantile digital fibromatosis--a histochemical study on distribution of sulfhydryl groups.
作者信息
Kanamori M, Hashimoto K, Tanaka H, Shimizu M
机构信息
Department of Dermatology, Mie University School of Medicine, Japan.
出版信息
J Dermatol. 1990 Sep;17(9):559-63. doi: 10.1111/j.1346-8138.1990.tb01695.x.
A case of infantile digital fibromatosis was studied with regard to the distribution of -SH groups and SS linkages, using N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain. Tumor cells showed a strong fluorescence in the cytoplasm from the -SH stain. A brilliant -SH fluorescence was also homogenously present on the intracytoplasmic inclusions. SS reactivity was negative. Although further studies should be necessary to ascertain this finding, the DACM stain may make a simple and objective diagnostic method of infantile digital fibromatosis.
采用N-(7-二甲基氨基-4-甲基-3-香豆素基)马来酰亚胺（DACM）染色法，对1例婴儿指纤维瘤病的巯基(-SH)基团分布和二硫键(SS)连接情况进行了研究。肿瘤细胞经巯基染色后，胞质内呈现强烈荧光。胞质内包涵体也均匀呈现明亮的巯基荧光。二硫键反应呈阴性。尽管需要进一步研究来证实这一发现，但DACM染色可能成为婴儿指纤维瘤病一种简单而客观的诊断方法。
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