von Boyen Georg, Steinkamp Martin
Department of Internal Medicine I (Gastroenterology), University of Ulm, Ulm, Germany.
Neuron Glia Biol. 2010 Nov;6(4):231-6. doi: 10.1017/S1740925X11000068. Epub 2011 Jul 21.
A neuro-glia interaction is part of gut inflammation and essential for the integrity of the bowel. A loss of enteric glia cells (EGCs) led to a fatal haemorrhagic jejuno-ileitis and death in a few days. Although a diminished EGC network is postulated in inflammatory bowel disease and enteric glia pathology is described in Chagas' disease the role of EGCs in the onset of these disease complexes is not definitely clear. Several lines of evidence implicate that the secretion of different factors by enteric glia may be the key for modulating gut homeostasis. As mucosal integrity might be important for remission in Crohn's disease and inflammation of the enteric nervous system is part of the pathology in Chagas' disease, the role of EGCs during gut inflammation could be part of the key to understand these diseases.
神经胶质细胞相互作用是肠道炎症的一部分，对肠道完整性至关重要。肠神经胶质细胞（EGC）的缺失会导致致命的出血性空肠回肠炎，并在数天内死亡。尽管在炎症性肠病中推测EGC网络减少，且在恰加斯病中描述了肠神经胶质细胞病理学，但EGC在这些疾病复合体发病中的作用尚不完全清楚。有几条证据表明，肠神经胶质细胞分泌不同因子可能是调节肠道内环境稳定的关键。由于黏膜完整性可能对克罗恩病的缓解很重要，且肠神经系统炎症是恰加斯病病理学的一部分，EGC在肠道炎症期间的作用可能是理解这些疾病的关键部分。
