Department of Oral & Craniofacial Health Sciences, College of Dentistry, University of Sharjah, Sharjah, United Arab Emirates.
Arch Oral Biol. 2012 Jan;57(1):1-9. doi: 10.1016/j.archoralbio.2011.06.013. Epub 2011 Jul 19.
Saliva is an important body fluid containing a complex mixture of proteins, peptides and other substances. These are not only important in maintaining the health of the oral cavity but also may yield information about oral and systemic disease. Comprehensive analysis and identification of the proteomic content of human saliva may contribute to the understanding of oral pathophysiology and provide a foundation for the recognition of potential biomarkers of human disease. The collection of saliva samples is non-invasive, safe, and inexpensive. It seems likely that testing methods can be developed which can be used in general medical or dental practice. However, it is important to realize that the collection of saliva must be carefully controlled. In this paper we review the progress in the analysis of the human salivary proteome and summarise the diagnostic possibilities that have been explored. The precautions in collecting saliva, and some of the factors which would have to be considered if a diagnostic test were to be generally adopted are discussed.
唾液是一种重要的体液，其中含有复杂的蛋白质、肽和其他物质混合物。这些物质不仅对维持口腔健康很重要，而且可能提供有关口腔和全身疾病的信息。全面分析和鉴定人类唾液中的蛋白质组内容可能有助于了解口腔生理学，并为识别人类疾病的潜在生物标志物提供基础。收集唾液样本是无创、安全且廉价的。似乎有可能开发出可以在一般医疗或牙科实践中使用的测试方法。然而，重要的是要意识到唾液的收集必须得到严格控制。本文综述了人类唾液蛋白质组分析的进展，并总结了已探索的诊断可能性。讨论了收集唾液时的注意事项，以及如果要普遍采用诊断测试，将不得不考虑的一些因素。
