Department of Community Health Sciences, University of Calgary, Calgary, Canada.
J Affect Disord. 2011 Nov;134(1-3):288-93. doi: 10.1016/j.jad.2011.06.027. Epub 2011 Jul 19.
Previous studies have linked major depressive episodes (MDEs) to obesity. The association may be partially mediated by antidepressant medication use. In the current study we examine changes in weight and BMI in relation to MDE and antidepressant use in a general population cohort.
Data from a Canadian longitudinal study, the National Population Health Survey (NPHS) were used. The NPHS has collected data from a community cohort since 1994 using interviews spaced two years apart. The NPHS includes the Composite International Diagnostic Interview Short Form for Major Depression (CIDI-SFMD). Self-reported height and weight are also recorded. Linear regression was used to describe associations between weight, BMI and MDE.
The pattern of weight change varied by age. Respondents under the age of 65 tended to gain weight over time, whereas those over the age of 65 tended to lose weight. Respondents in the younger category gained more weight if they had MDE or took antidepressant medications. However, the extent of weight gain was modest, those with MDE and those taking an antidepressant gaining an average of approximately 1 kg over 12 years of follow-up.
The study used self-reported weight, which may be inaccurate. Measurements were made two years apart. The measure of MDE was an abbreviated diagnostic interview.
Both MDE and antidepressant medication use are associated with a modest increase in weight in people under 65. These results may be useful for physicians and other health professionals in planning dietary and weight-management regimens for depressed patients.
先前的研究表明，重度抑郁发作（MDE）与肥胖有关。这种关联可能部分是由抗抑郁药物的使用所介导的。在目前的研究中，我们在一个普通人群队列中检查了 MDE 和抗抑郁药使用与体重和 BMI 变化的关系。
使用了加拿大纵向研究——国家人口健康调查（NPHS）的数据。NPHS 自 1994 年以来每隔两年使用访谈收集来自社区队列的数据。NPHS 包括复合国际诊断访谈简短形式的主要抑郁障碍（CIDI-SFMD）。也记录了自我报告的身高和体重。线性回归用于描述体重、BMI 和 MDE 之间的关联。
体重变化的模式因年龄而异。年龄在 65 岁以下的受访者随着时间的推移往往会增加体重，而年龄在 65 岁以上的受访者往往会减轻体重。如果有 MDE 或服用抗抑郁药物，年轻组的受访者体重增加更多。然而，体重增加的幅度适中，有 MDE 和服用抗抑郁药的人在 12 年的随访中平均增加了约 1 公斤。
该研究使用的是自我报告的体重，可能不准确。测量间隔两年进行。MDE 的测量是一个简短的诊断访谈。
MDE 和抗抑郁药物的使用与 65 岁以下人群体重的适度增加有关。这些结果对于医生和其他卫生专业人员为抑郁患者制定饮食和体重管理方案可能是有用的。
