鞘氨醇-1-磷酸诱导的血管收缩在糖尿病大鼠离体灌注肾脏中增加。
Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats.
机构信息
Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, México City, Mexico.
出版信息
Diabetes Res Clin Pract. 2011 Oct;94(1):e8-11. doi: 10.1016/j.diabres.2011.06.023. Epub 2011 Jul 20.
Abstract
We observed that in isolated perfused rat kidneys, sphingosine-1-phosphate produces S1P(2) receptor-mediated vasoconstriction, and this response increased in kidneys of diabetic rats. These results suggest that the antagonists of S1P(2) receptor may have potential as drugs to control diabetes-induced vascular complications.
摘要
我们观察到，在分离的灌注大鼠肾脏中，鞘氨醇-1-磷酸产生 S1P(2) 受体介导的血管收缩，并且这种反应在糖尿病大鼠的肾脏中增加。这些结果表明，S1P(2) 受体拮抗剂可能具有作为控制糖尿病引起的血管并发症的药物的潜力。
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