Electrical Engineering Department, Stanford University, CA 94305, USA.
IEEE Trans Med Imaging. 2012 Apr;31(4):938-47. doi: 10.1109/TMI.2011.2162248. Epub 2011 Jul 18.
Radio-frequency ablation (RFA) is an effective minimally invasive treatment for tumors. One primary source of difficulty is monitoring and controlling the ablation region. Currently, RFA is performed at 460 kHz, for which magnetic resonance imaging (MRI) could play a role given its capability for temperature monitoring and tumor visualization. If instead the ablation were to be performed at the MRI Larmor frequency, then the MR capability for B(1) field mapping could be used to directly visualize the radio-frequency (RF) fields created by the ablation currents. Visualizing the RF fields may enable better control of the ablation currents, enabling better control of lesion shape and size and improving repeatability. We demonstrate the feasibility of performing RFAs at 64 MHz and show preliminary results from imaging the RF fields from the ablation. The post-ablation RF fields show an increase in current density in the ablated region, consistent with an increase in conductivity of the ablated tissue.
射频消融(RFA)是一种有效的肿瘤微创治疗方法。其中一个主要的难点是监测和控制消融区域。目前,RFA 的频率为 460 kHz,而磁共振成像(MRI)可以在温度监测和肿瘤可视化方面发挥作用。如果将消融频率改为 MRI 的拉莫尔频率,那么 MRI 对 B(1)场映射的能力就可以用来直接观察由消融电流产生的射频(RF)场。可视化 RF 场可以更好地控制消融电流,从而更好地控制病变形状和大小,提高重复性。我们证明了在 64 MHz 下进行 RFAs 的可行性,并展示了从消融产生的 RF 场成像的初步结果。消融后的 RF 场显示出消融区域电流密度的增加,这与消融组织的电导率增加一致。