Department of General Surgery, Center of Diagnosis and Treatment of Vascular Ulcers, Villa Fiorita Clinic, Prato, Italy.
Panminerva Med. 2011 Sep;53(3):185-91.
The aim of this study was to assess a spray formulation containing colloidal silver and hyaluronic acid.
Patients included in the study were divided in two separate groups: 30 patients had chronic wounds and 24 patients had superficial traumatic wounds. Applications were performed at intervals of 3-7 days, depending upon lesions characteristics. Subsequent improvements were evaluated at various intervals after enrollment. The lesion area and the rate of re-epithelialization were calculated, considering the time span and monitoring the patients for clinical signs of wound infection. Patients satisfaction and compliance were evaluated by a questionnaire aimed at assessing pain and ease of use of the device.
Chronic lesions were healed at week 12, with a high rate of closure observed at 6 weeks (70%). Furthermore, traumatic wounds healed at six weeks, with a substantial percentage of closure (80%) at three weeks. A good control of microbial contamination was evident in all the treated wounds; in no case other antimicrobial medications were used. Finally, patients favorably expressed compliance with regard to the spray formulation and ease of use.
This type of clinical approach seems to be a rational good choice to promote re-epithelialization of superficial cutaneous ulcers of different origins as well as control of bacterial infections.
本研究旨在评估一种含有胶体银和透明质酸的喷雾制剂。
研究纳入的患者分为两组：30 例慢性伤口患者和 24 例浅创伤性伤口患者。根据病变特点，每隔 3-7 天进行一次应用。入组后不同时间点评估后续改善情况。计算病变面积和再上皮化率，考虑时间跨度并监测患者的伤口感染临床征象。通过问卷调查评估患者的满意度和依从性，该问卷旨在评估疼痛和使用设备的便利性。
慢性病变在第 12 周愈合，第 6 周观察到高闭合率（70%）。此外，创伤性伤口在 6 周内愈合，第 3 周的闭合率（80%）较高。所有治疗的伤口均明显控制了微生物污染；在任何情况下都未使用其他抗菌药物。最后，患者对喷雾制剂的使用便利性和依从性表示满意。
这种临床方法似乎是促进不同来源的浅表皮溃疡再上皮化和控制细菌感染的合理选择。
