Sumant Khanna, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore - 560 029.
Indian J Psychiatry. 1992 Jul;34(3):264-72.
Seventy two subjects with OCD were compared with 18 normal healthy volunteers on multiple neuroendocrine responses to clonidine. Significant heterogeneity in OCD was observed in responses of growth hormone. There was also significant disturbances in Cortisol and ACTH release. An interactional model for noradrenergic and serotonergic dysfunction in OCD is discussed.
72 例强迫症患者与 18 例正常健康志愿者进行了多项神经内分泌对可乐定反应的比较。生长激素反应在强迫症中存在显著的异质性。皮质醇和促肾上腺皮质激素释放也存在显著紊乱。讨论了强迫症中去甲肾上腺素能和 5-羟色胺能功能障碍的相互作用模型。
