Zhang Xiaofeng, Toronov Vladislav Y, Fabiani Monica, Gratton Gabriele, Webb Andrew G
Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
Proc SPIE Int Soc Opt Eng. 2005;5686(115):566-572. doi: 10.1117/12.593435.
The integration of near-infrared (NIR) and functional MRI (fMRI) studies is potentially a powerful method to investigate the physiological mechanism of human cerebral activity. However, current NIR methodologies do not provide adequate accuracy of localization and are not fully integrated with MRI in the sense of mutual enhancement of the two imaging modalities. Results are presented to address these issues by developing an MRI-compatible optical probe and using diffuse optical tomography for optical image reconstruction. We have developed a complete methodology that seamlessly integrates NIR tomography with fMRI data acquisition. In this paper, we apply this methodology to determine both hemodynamic and early neuronal responses in the visual cortex in humans. Early results indicate that the changes in deoxyhemoglobin concentration from optical data are co-localized with fMRI BOLD signal changes, but changes in oxyhemoglobin concentration (not measurable using fMRI) show interesting spatial differences.
将近红外（NIR）研究与功能磁共振成像（fMRI）相结合，可能是一种研究人类大脑活动生理机制的有力方法。然而，目前的近红外方法在定位准确性方面存在不足，并且在两种成像方式相互增强的意义上，尚未与磁共振成像完全整合。本文展示了通过开发一种与磁共振成像兼容的光学探头，并使用扩散光学断层扫描进行光学图像重建来解决这些问题的结果。我们已经开发出一种完整的方法，能够将近红外断层扫描与功能磁共振成像数据采集无缝整合。在本文中，我们应用这种方法来确定人类视觉皮层中的血流动力学和早期神经元反应。早期结果表明，光学数据中脱氧血红蛋白浓度的变化与功能磁共振成像的血氧水平依赖（BOLD）信号变化共定位，但氧合血红蛋白浓度的变化（功能磁共振成像无法测量）显示出有趣的空间差异。
