Zhang Xiaofeng, Toronov Vladislav Y, Webb Andrew G
Department of Bioengineering, Pennsylvania State University, University Park, PA 16802.
Rev Sci Instrum. 2006 Nov;77(11):114301-1143018. doi: 10.1063/1.2364138.
An integrated measurement system is described for performing simultaneous functional magnetic resonance imaging (fMRI) and diffuse optical tomography (DOT) for human brain mapping experiments. The components of this system consist of an MRI-compatible multi-overlapping-channel optical probe, methods for co-registration of optical and fMRI measurements, and DOT reconstruction algorithms with structural and physiological constraints derived from the MRI data. The optical probe is fully MRI-compatible in the sense that it produces negligible MR image distortion and does not require any modification to the MRI scanner or data acquisition protocol. The probe can be attached to any part of the head without posing any limitation on optical data acquisition. Co-registration of images from fMRI and optical measurements was achieved by localizing the positions of the optical fibers using MRI markers. Human studies show successful implementation of the entire system.
本文描述了一种集成测量系统，用于在人类脑图谱实验中同时进行功能磁共振成像（fMRI）和扩散光学断层扫描（DOT）。该系统的组件包括一个与MRI兼容的多重叠通道光学探头、光学和fMRI测量的共配准方法，以及基于MRI数据推导的具有结构和生理约束的DOT重建算法。该光学探头在产生可忽略不计的MR图像失真且无需对MRI扫描仪或数据采集协议进行任何修改的意义上与MRI完全兼容。该探头可以连接到头部的任何部位，而不会对光学数据采集造成任何限制。通过使用MRI标记定位光纤位置，实现了fMRI和光学测量图像的共配准。人体研究表明整个系统已成功实施。
