Winter Carl K, Katz Josh M
Department of Food Science and Technology, University of California, One Shields Avenue, Davis, CA 95616, USA.
J Toxicol. 2011;2011:589674. doi: 10.1155/2011/589674. Epub 2011 May 15.
Probabilistic techniques were used to characterize dietary exposure of consumers to pesticides found in twelve commodities implicated as having the greatest potential for pesticide residue contamination by a United States-based environmental advocacy group. Estimates of exposures were derived for the ten most frequently detected pesticide residues on each of the twelve commodities based upon residue findings from the United States Department of Agriculture's Pesticide Data Program. All pesticide exposure estimates were well below established chronic reference doses (RfDs). Only one of the 120 exposure estimates exceeded 1% of the RfD (methamidophos on bell peppers at 2% of the RfD), and only seven exposure estimates (5.8 percent) exceeded 0.1% of the RfD. Three quarters of the pesticide/commodity combinations demonstrated exposure estimates below 0.01% of the RfD (corresponding to exposures one million times below chronic No Observable Adverse Effect Levels from animal toxicology studies), and 40.8% had exposure estimates below 0.001% of the RfD. It is concluded that (1) exposures to the most commonly detected pesticides on the twelve commodities pose negligible risks to consumers, (2) substitution of organic forms of the twelve commodities for conventional forms does not result in any appreciable reduction of consumer risks, and (3) the methodology used by the environmental advocacy group to rank commodities with respect to pesticide risks lacks scientific credibility.
概率技术被用于描述消费者通过十二种商品接触农药的膳食暴露情况。这十二种商品被一家美国环境倡导组织认为具有农药残留污染的最大潜在风险。根据美国农业部农药数据计划的残留检测结果,得出了这十二种商品中每种商品上十种最常检测到的农药残留的暴露估计值。所有农药暴露估计值均远低于既定的慢性参考剂量(RfDs)。120个暴露估计值中只有一个超过了参考剂量的1%(辣椒上的甲胺磷为参考剂量的2%),只有七个暴露估计值(5.8%)超过了参考剂量的0.1%。四分之三的农药/商品组合的暴露估计值低于参考剂量的0.01%(相当于暴露水平比动物毒理学研究中的慢性无可见不良影响水平低一百万倍),40.8%的暴露估计值低于参考剂量的0.001%。得出的结论是:(1)通过这十二种商品接触最常检测到的农药对消费者造成的风险可忽略不计;(2)用这十二种商品的有机形式替代传统形式不会显著降低消费者风险;(3)环境倡导组织用于对商品的农药风险进行排名的方法缺乏科学可信度。