Markoula Sofia, Chatzikyriakidou Anthoula, Giannopoulos Sotirios, Odysseas Kargiotis, Markou Sofia, Vemmos Konstantinos, Georgiou Ioannis, Kyritsis Athanassios P
Department of Neurology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, Greece.
Stroke Res Treat. 2011;2011:920584. doi: 10.4061/2011/920584. Epub 2011 May 29.
Background. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role of TNF-857C>T,TNFRSF1A36A>G, and TNFRSF1B676T>G polymorphisms in risk for stroke. Materials and Methods. One hundred seventy-three patients with first ever ischemic stroke of solely atherosclerotic etiology in Northwest Greece and a control group of 179 healthy unrelated subjects were evaluated. Results. TNFα-857TT, TNFR136AA, and TNFR2676TT genotypes were significantly increased in the patient group compared to controls (P = .008, OR = 2.47 (1.26-4.84), P = .005, OR = 1.97 (1.22-3.17), and P = .003, OR = 2.2 (1.43-3.37), resp.). In addition, the TNFR136A and the TNFR2676T alleles were found significantly increased in patients compared to controls (P = .009, OR = 1.48 (1.1-2) and P = .001, OR = 1.75 (1.25-2.46), resp.). Conclusion. The high incidence of these genotypes and alleles in patient group suggests that they are potentially predisposing factors for stroke in the Greek population studied. Large-scale multicenter controlled studies are needed to verify these polymorphisms effects on stroke susceptibility.
背景。先前的研究已评估了遗传因素在缺血性中风易感性中的作用。本研究的主要目的是确定TNF-857C>T、TNFRSF1A36A>G和TNFRSF1B676T>G多态性在中风风险中的任何可能作用。材料与方法。对希腊西北部173例首次发生的仅由动脉粥样硬化病因引起的缺血性中风患者以及179名健康无关受试者的对照组进行了评估。结果。与对照组相比，患者组中TNFα-857TT、TNFR136AA和TNFR2676TT基因型显著增加（分别为P = 0.008，OR = 2.47（1.26 - 4.84）；P = 0.005，OR = 1.97（1.22 - 3.17）；P = 0.003，OR = 2.2（1.43 - 3.37））。此外，与对照组相比，患者中TNFR136A和TNFR2676T等位基因显著增加（分别为P = 0.009，OR = 1.48（1.1 - 2）；P = 0.001，OR = 1.75（1.25 - 2.46））。结论。患者组中这些基因型和等位基因的高发生率表明，它们可能是所研究希腊人群中风的易感因素。需要进行大规模多中心对照研究来验证这些多态性对中风易感性的影响。
