[Morphogenetic study on hyperplastic and neoplastic diseases of endocrine pancreas].

A morphologic study was conducted on nesidioblastosis, islet cell hyperplasia, adenomatous hyperplasia of islets of Langerhans and true islet cell adenoma with histochemical, immunohistochemical, electron microscopic and morphometric techniques. The results showed that the morphologic features of these four diseases were correlated with the development of pancreas and to a certain extent duplicated the process of fetal development. These findings seem to support the hypothesis that there exists a full spectrum of conditions ranging from the original nesidioblastosis to islet cell hyperplasia, adenomatosis and true islet cell adenoma.