Sen A P, Bhattacharya S K, Rao P R
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1990 Oct;28(10):943-5.
Potential-dependent calcium channels have been studied in the isolated rabbit jejunum. A biphasic response was observed, a transient and rapid contraction followed by partial relaxation and a sustained contraction attaining a plateau state. These are similar to the phasic and tonic responses observed in the isolated smooth muscles of other species. Both the responses are susceptible to blockade by the calcium antagonists bepridil, diltiazem, nifedipine, PN 200-110 (isradipine), and verapamil. Two calcium pools or the presence of two channels affecting the two responses are proposed.
在离体兔空肠中对电压依赖性钙通道进行了研究。观察到双相反应，先是短暂快速收缩，随后部分舒张，接着是持续收缩并达到平台期。这些反应与在其他物种的离体平滑肌中观察到的相性和紧张性反应相似。两种反应均易被钙拮抗剂苄普地尔、地尔硫䓬、硝苯地平、PN 200 - 110（伊拉地平）和维拉帕米阻断。研究提出存在两个钙池或两种通道影响这两种反应。
