Batra S K, Brown S M
MRC Virology Unit, Institute of Virology, Glasgow, Scotland.
Indian J Exp Biol. 1990 Oct;28(10):960-3.
The virulence of herpes simplex virus (HSV) type 1 x type 2 intertypic recombinants was determined following infection of corneas of outbred New Zealand White rabbits. None of the four recombinants was as virulent for rabbits as type 1 parent. All the four recombinants having an insert of type 2 virus genome between 0.35 and 0.576 map units (m.u.) and/or 0.82 and 1.00 m.u. exhibited intermediate virulence between their type 1 and type 2 parents. The results indicate that intertypic recombinants are moderated in their virulence independent of their parental virulence and therefore there exists a multigenic control of HSV virulence.
在对远交系新西兰白兔的角膜进行感染后，测定了单纯疱疹病毒1型（HSV-1）与2型（HSV-2）的种间重组体的毒力。四种重组体对兔子的毒力均不如1型亲本。所有四种在0.35至0.576图谱单位（m.u.）和/或0.82至1.00 m.u.之间插入2型病毒基因组的重组体，其毒力介于1型和2型亲本之间。结果表明，种间重组体的毒力受到调节，与其亲本毒力无关，因此单纯疱疹病毒的毒力存在多基因控制。
