Ghosh D, Biswas N M, Chaudhuri A, Ghosh P K
Department of Physiology, University Colleges of Science and Technology, Calcutta University, India.
Indian J Exp Biol. 1990 Sep;28(9):801-5.
Activities of delta 5-3 beta- and 17 beta-hydroxysteroid dehydrogenase (delta 5-3 beta-HSD and 17 beta-HSD), Leydig cell nuclear area (LCNA) and spermatogenesis in the testis were observed after injection of lithium chloride in the 'antiserum to luteinizing hormone (LH)' treated toad. A significant decrease in the activities of steroidogenic enzymes, LCNA and spermatogenesis were noticed after the injections of 'antiserum to LH' to toads. Further decrease in the activities of the above parameters was observed in the lithium chloride--'antiserum to LH' treated toad. It is suggested that lithium chloride may inhibits testicular function without modulating the pituitary activity.
在给用“抗促黄体生成素（LH）抗血清”处理过的蟾蜍注射氯化锂后，观察了睾丸中δ5-3β-和17β-羟基类固醇脱氢酶（δ5-3β-HSD和17β-HSD）的活性、睾丸间质细胞核面积（LCNA）和精子发生情况。给蟾蜍注射“抗LH抗血清”后，类固醇生成酶的活性、LCNA和精子发生均显著降低。在氯化锂-“抗LH抗血清”处理的蟾蜍中，上述参数的活性进一步降低。提示氯化锂可能在不调节垂体活性的情况下抑制睾丸功能。
