Biological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester M139PL, UK.
Prog Biophys Mol Biol. 2011 Oct;107(1):183-92. doi: 10.1016/j.pbiomolbio.2011.07.004. Epub 2011 Jul 13.
We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour.
我们将虚拟组织工程应用于足月人体子宫，以期重建通过细胞内钙控制机械活动的子宫肌电活动的时空模式。通过分段体内磁共振成像和离体扩散张量磁共振成像重建妊娠子宫的三维几何形状，以解决精细的组织结构。使用连续算法构建晚期妊娠子宫平滑肌细胞模型并进行爆发分析。将这些细胞模型纳入组织同步和传播的偏微分方程模型中。最终目标是开发一种对启动和调节分娩的机制的定量和预测性理解。
