Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.
Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois.
J Am Acad Dermatol. 2011 Sep;65(3):624-635. doi: 10.1016/j.jaad.2010.06.051. Epub 2011 Jul 20.
Cancer therapies have led to remarkable results due to improved toxicity profiles and effects on survival. While these medical, surgical, and radiation protocols are chiefly responsible for these noteworthy contributions, an unexpected constellation of toxicities has emerged. Most notably, dermatologic adverse events have gained considerable attention, due to their high frequency, visibility, and impact on physical and psychosocial health, all of which affect dose intensity and possibly clinical outcome. Consequently, increased attention to cutaneous health in oncology has resulted in supportive oncodermatology clinical programs and toxicity-driven investigations, aiming to mitigate these untoward events and permit the continued optimization of cancer treatments.
癌症治疗由于改善了毒性特征和对生存的影响而取得了显著的效果。虽然这些医学、手术和放射治疗方案主要负责这些显著的贡献,但出现了一组意想不到的毒性。由于其高频率、可见性和对身体和社会心理健康的影响,皮肤科不良事件引起了相当大的关注,所有这些都影响剂量强度和可能的临床结果。因此,对肿瘤学中皮肤健康的更多关注导致了支持性肿瘤皮肤病学临床方案和毒性驱动的研究,旨在减轻这些不良事件,并允许继续优化癌症治疗。