Basrah Maternity and Children Hospital, College of Medicine, University of Basrah, Basrah, Iraq.
Acta Haematol. 2011;126(3):157-62. doi: 10.1159/000328416. Epub 2011 Jul 20.
This prospective study was carried out to assess lactate dehydrogenase (LDH) as a biochemical marker during acute painful episode and steady state in children with sickle cell disease (SCD).
A prospective descriptive study has been carried out on children and adolescents with SCD and pain during a vaso-occlusive episode. A total of 76 patients aged 1-18 years were included. Assessment of pain was done using the suitable pain assessment tool (visual analogue scales, Oucher scale) for school and preschool children. Complete blood count, liver function tests, LDH and C-reactive protein assay were performed on all patients during acute painful episode and steady state.
LDH has been found to increase significantly during acute painful episode compared with steady state (p < 0.01). There is also a significant positive correlation between LDH level and severity of pain (p < 0.05). In addition, C-reactive protein level was found to be significantly elevated during acute painful episode (p < 0.01) and its level correlates significantly with severity of pain (p = 0.01).
From this study it can be concluded that LDH is a significant biochemical marker for the severity of pain during a vaso-occlusive episode in SCD.
本前瞻性研究旨在评估乳酸脱氢酶（LDH）在镰状细胞病（SCD）儿童急性疼痛发作和稳定期的生化标志物作用。
对 SCD 伴疼痛发作的儿童和青少年进行了一项前瞻性描述性研究。共纳入 76 名 1-18 岁的患者。对学龄和学龄前儿童使用适当的疼痛评估工具（视觉模拟量表、Oucher 量表）进行疼痛评估。所有患者在急性疼痛发作和稳定期均进行全血细胞计数、肝功能检查、LDH 和 C-反应蛋白检测。
LDH 在急性疼痛发作时显著升高，与稳定期相比（p < 0.01）。LDH 水平与疼痛严重程度呈显著正相关（p < 0.05）。此外，在急性疼痛发作时 C-反应蛋白水平显著升高（p < 0.01），其水平与疼痛严重程度显著相关（p = 0.01）。
本研究表明，LDH 是 SCD 血管阻塞性发作时疼痛严重程度的重要生化标志物。
