韩国人胃底腺息肉及其与结直肠肿瘤的关系：一项16年的回顾性研究。

Gastric fundic gland polyps and their relationship to colorectal neoplasia in Koreans: a 16-year retrospective study.

作者信息

Hwang Sun-Mee, Kim Byung-Wook, Chae Hiun-Suk, Lee Bo-In, Choi Hwang, Ji Jeong-Seon, Choi Kyu-Yong, Chung In-Sik, Maeng Lee-So

机构信息

Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea.

出版信息

Korean J Gastroenterol. 2011 Jul;58(1):20-4. doi: 10.4166/kjg.2011.58.1.20.

DOI:10.4166/kjg.2011.58.1.20

PMID:21778799

Abstract

BACKGROUND/AIMS: There is an ongoing debate on the relationship between gastric fundic gland polyps and increased incidence of colorectal neoplasia in Caucasians. However, there was no report on the relationship between gastric fundic gland polyp and colorectal neoplasia in Korea. The aim of this study was to identify the characteristics of gastric fundic gland polyps and whether a relationship exists between fundic gland polyps and colorectal neoplasia in Korean population.

METHODS

Persons who underwent an esophagogastroduodenoscopy and colonoscopy from 1992 to 2007 at the Health Promotion Center of Incheon St. Mary's Hospital, The Catholic University of Korea were reviewed retrospectively. The relationship between gastric fundic gland polyps and colorectal neoplasia were analyzed.

RESULTS

Among 22,451 subjects, fundic gland polyps were found in 328 subjects (1.5%). Fundic gland polyps were more common in women than in men (odds ratio of 6.25; 95% CI of 4.68-8.34). The odds ratios for colorectal neoplasia in all subjects with gastric fundic gland polyps were 0.56 (95% CI of 0.33-0.95) and men who were 50 years of age or older had an odds ratio of 2.81 (95% CI of 1.03-7.66) as compared to the control group. However, age and sex-adjusted odds ratios for all gastric fundic gland polyps were 0.73 (95% CI of 0.42-1.26), for men 1.78 (95% CI of 0.80-3.98), and for women 0.37 (95% CI of 0.16-0.87).

CONCLUSIONS

Surveillance colonoscopy in patients with fundic gland polyps can be performed in the same manner as general population in Korea.

摘要

背景/目的：关于胃底腺息肉与高加索人群结直肠肿瘤发病率增加之间的关系，目前仍存在争议。然而，韩国尚无关于胃底腺息肉与结直肠肿瘤关系的报道。本研究的目的是确定韩国人群胃底腺息肉的特征，以及胃底腺息肉与结直肠肿瘤之间是否存在关联。

方法

回顾性分析1992年至2007年在韩国天主教大学仁川圣母医院健康促进中心接受食管胃十二指肠镜检查和结肠镜检查的患者。分析胃底腺息肉与结直肠肿瘤之间的关系。

结果

在22451名受试者中，328名（1.5%）发现有胃底腺息肉。胃底腺息肉在女性中比男性更常见（优势比为6.25；95%置信区间为4.68 - 8.34）。所有患有胃底腺息肉的受试者中，结直肠肿瘤的优势比为0.56（95%置信区间为0.33 - 0.95），50岁及以上男性与对照组相比优势比为2.81（95%置信区间为1.03 - 7.66）。然而，对所有胃底腺息肉进行年龄和性别调整后的优势比，总体为0.73（95%置信区间为0.42 - 1.26），男性为1.78（95%置信区间为0.80 - 3.98），女性为0.37（95%置信区间为0.16 - 0.87）。