Wichmann H E, Molik B, Jöckel K H, Jahn I, Müller K M
Bergische Universität Gesamthochschule Wuppertal.
Pneumologie. 1990 Nov;44(11):1251-8.
In a case-control study to examine the risk factors for bronchial carcinoma, 194 histologically confirmed cases of lung cancer and twice the number of controls (194 hospital controls, 194 population controls) were covered. In addition, the histological material obtained from 139 patients was assessed by a reference pathologist. In 107 cases (77%) the data coincided with the findings by the hospital pathologists. In women, young patients and persons with better general job qualifications adenocarcinomas and other bronchial carcinomas were seen more often and small-cell carcinomas as well as squamous cell carcinomas were rarer. Smoking did not entail any significant difference in respect of bronchial carcinoma risk. There was a significant risk increase among persons occupationally exposed to polycyclic aromatic hydrocarbons, arsenic, chromium, nickel and radionuclides in respect of squamous cell and small-cell carcinomas but not of adenocarcinomas and other histological types of carcinoma.
在一项旨在研究支气管癌危险因素的病例对照研究中,纳入了194例经组织学确诊的肺癌病例以及两倍数量的对照(194名医院对照、194名人群对照)。此外,一名参考病理学家对从139名患者获取的组织学材料进行了评估。在107例病例(77%)中,数据与医院病理学家的发现相符。在女性、年轻患者以及总体工作资质较好的人群中,腺癌和其他支气管癌更为常见,而小细胞癌和鳞状细胞癌则较为罕见。吸烟在支气管癌风险方面没有显著差异。在职业性接触多环芳烃、砷、铬、镍和放射性核素的人群中,鳞状细胞癌和小细胞癌的风险显著增加,但腺癌和其他组织学类型的癌则不然。