Kawada N, Mizoguchi Y, Shin T, Tsutsui H, Kobayashi K, Morisawar S, Monna T, Yamamoto S
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1990 Nov;41(3):187-93. doi: 10.1016/0952-3278(90)90089-4.
When heat-killed Propionibacterium acnes (P. acnes) is intravenously injected into rats or mice, liver adherent cells including macrophages and Kupffer cells increase in number and they synthesize various kinds of biologically-active materials. We studied the production of eicosanoids and the cytokines, interleukin 1 (IL-1) and tumor necrosis factor (TNF), by P. acnes-elicited liver adherent cells and the regulatory mechanisms of eicosanoids in the synthesis of cytokines. As a result, P. acnes-elicited liver adherent cells synthesized not only prostaglandin (PG) E2, 6-keto-PGF1 alpha, thromboxane B2 and leukotriene B4, but also IL-1 and TNF. In addition, PGE2 and PGI2 suppressed the production of these cytokines. These results suggested that there are auto-regulatory mechanisms in production of cytokines in the liver.
当将热灭活的痤疮丙酸杆菌（P. acnes）静脉注射到大鼠或小鼠体内时，包括巨噬细胞和库普弗细胞在内的肝脏黏附细胞数量会增加，并且它们会合成各种生物活性物质。我们研究了痤疮丙酸杆菌诱导的肝脏黏附细胞产生类花生酸以及细胞因子白细胞介素1（IL-1）和肿瘤坏死因子（TNF）的情况，以及类花生酸在细胞因子合成中的调节机制。结果，痤疮丙酸杆菌诱导的肝脏黏附细胞不仅合成前列腺素（PG）E2、6-酮-PGF1α、血栓素B2和白三烯B4，还合成IL-1和TNF。此外，PGE2和PGI2抑制了这些细胞因子的产生。这些结果表明肝脏中细胞因子的产生存在自动调节机制。
