p53在代谢调节中的作用。
The Role of p53 in Metabolic Regulation.
作者信息
Puzio-Kuter Anna M
机构信息
Cancer Institute of New Jersey, New Brunswick, NJ, USA.
出版信息
Genes Cancer. 2011 Apr;2(4):385-91. doi: 10.1177/1947601911409738.
Abstract
The metabolic changes that occur in a cancer cell have been studied for a few decades, but our appreciation of the complexity and importance of those changes is now being realized. The metabolic switch from oxidative phosphorylation to aerobic glycolysis provides intermediates for cell growth and division and is regulated by both oncogenes and tumor suppressor genes. The p53 tumor suppressor gene has long been shown to play key roles in responding to DNA damage, hypoxia, and oncogenic activation. However, now p53 has added the ability to mediate metabolic changes in cells through the regulation of energy metabolism and oxidative stress to its repertoire of activities. It is therefore the focus of this review to discuss the metabolic pathways regulated by p53 and their cooperation in controlling cancer cell metabolism.
摘要
癌细胞中发生的代谢变化已经研究了几十年，但我们现在才认识到这些变化的复杂性和重要性。从氧化磷酸化到有氧糖酵解的代谢转换为细胞生长和分裂提供中间体，并受癌基因和肿瘤抑制基因的调控。长期以来，p53肿瘤抑制基因在应对DNA损伤、缺氧和致癌激活方面发挥着关键作用。然而，现在p53在其一系列活动中增加了通过调节能量代谢和氧化应激来介导细胞代谢变化的能力。因此，本综述的重点是讨论由p53调控的代谢途径及其在控制癌细胞代谢中的协同作用。
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