Deftos L J, Hogue-Angeletti R, Chalberg C, Tu S
Department of Medicine (Endocrine Division), University of California, La Jolla.
J Bone Miner Res. 1990 Sep;5(9):989-91. doi: 10.1002/jbmr.5650050913.
We studied the regulation of the secretion of CT and CGRP by chromogranin A (CgA)-derived peptides in a human lung tumor cell line. The amino-terminal peptide of CgA, CgA1-40, stimulated the secretion of CGRP and inhibited the secretion of CT; both effects occurred in a dose-dependent manner. These studies demonstrate a differential effect of a CgA-derived peptide on two products of the CT gene, CT itself and CGRP. CgA may be processed at its multiple dibasic sites to peptides that specifically regulate the secretion of its coresident hormones, in this case two calcitonin gene products that are present in the same secretory vesicle. This novel mechanism represents a new pathway for the control of calcium regulating hormones.
我们在一种人肺肿瘤细胞系中研究了嗜铬粒蛋白A（CgA）衍生肽对降钙素（CT）和降钙素基因相关肽（CGRP）分泌的调节作用。CgA的氨基末端肽CgA1 - 40刺激了CGRP的分泌并抑制了CT的分泌；这两种作用均呈剂量依赖性。这些研究证明了CgA衍生肽对CT基因的两种产物，即CT本身和CGRP具有不同的作用。CgA可能在其多个双碱性位点被加工成特定调节与其共定位激素分泌的肽，在这种情况下是存在于同一分泌囊泡中的两种降钙素基因产物。这种新机制代表了控制钙调节激素的一条新途径。
