College of Preclinical Medicine and Biological Science, Soochow University, Suzhou Jiangsu Province 215123, PR China.
Dev Psychobiol. 2012 Mar;54(2):133-8. doi: 10.1002/dev.20589. Epub 2011 Jul 20.
Prenatal aluminum exposure may affect the development of the embryo and alter the capacity for learning and memory in adults. The chick embryo is a good experimental model to study the effect of prenatal toxin exposure on cognitive defects in offspring, because it eliminates maternal confounding variables. In the present study, we applied a one-trial passive avoidance-learning task in day-old chicks to examine the effects of prenatal aluminum chloride injections (2, 20, and 200 mM in 200 µl per egg, daily over a period of 4 successive days) on memory consolidation. The data suggest that chicks injected with aluminum chloride (20 mM) daily from E12 to E15 had significantly impaired short-term memory, intermediate-term memory, and long-term memory (LTM) after training (p < .05) but chicks injected with aluminum chloride (2 mM) had impaired LTM only.
产前铝暴露可能会影响胚胎的发育，并改变成年人的学习和记忆能力。鸡胚是研究产前毒素暴露对后代认知缺陷影响的良好实验模型，因为它消除了母体混杂变量。在本研究中，我们在 1 日龄小鸡中应用了单次被动回避学习任务，以研究产前氯化铝注射（每天 4 天，每天 200μl 中 2、20 和 200mM）对记忆巩固的影响。数据表明，从 E12 到 E15 每天注射氯化铝（20mM）的小鸡在训练后短期记忆、中期记忆和长期记忆（LTM）明显受损（p<0.05），但注射氯化铝（2mM）的小鸡仅 LTM 受损。
