Urology Department, "S. Pio da Pietrelcina" Hospital, Vasto, Italy.
Neurourol Urodyn. 2011 Nov;30(8):1571-5. doi: 10.1002/nau.21157. Epub 2011 Jul 20.
To investigate the relationship between urinary flow rate and ejaculation in healthy young men.
Young men were voluntarily enrolled in the study. All subjects were healthy, and sexually active, without neurological diseases, genital, or urethral surgery and they were not under any medications. Subjects were evaluated with ultrasound, uroflowmetry, and post-void residual urine (PVR) measurement. All subjects were followed for 22 days (T) with daily uroflowmetry, and were instructed to ejaculate only on specific days (0, 6 and 22) during the study period. On days 0, 6 and 22 uroflow measurements were performed between 2 and 6 hr following ejaculation. Uroflowmetry parameters before and after ejaculation and during abstinence were compared. Data presented a non-normal distribution and the non-parametric Wilcoxon-match-paired test and Kruskal-Wallis test were used for statistical analysis.
18 subjects (mean age 27.4 years) completed the study. A total of 414 uroflow charts were collected. A statistical significant increase in Qmax was observed after ejaculation (T-1 Qmax: 22.7 ± 5.4 vs. T0 Qmax: 25.7 ± 8, P = 0.002; T5 Qmax 23.2 ± 5.4 vs. T6 Qmax 25.4 ± 8, P = 0.031; T21 Qmax 21 ± 4.8 vs. T22 Qmax 24.5 ± 7.9, P = 0.031). Sexual abstinence resulted in a progressive, statistically significant decline in Qmax rates (T0 Qmax 25.7 ± 8 vs. T5 23.2 ± 5.4 P = 0.035; T6 Qmax 25.4 ± 8 vs. T21 Qmax 21 ± 4.8, P = 0.01). PVR did not change during the study period.
Our results suggest that in young healthy men micturition might be influenced by ejaculation. Our findings, if confirmed in larger series of patients with LUTS, should support that sexual status and activity could represent an important confounding factor in the interpretation of uroflowmetry traces.
探讨健康年轻男性的尿流率与射精之间的关系。
年轻男性自愿参加研究。所有受试者均健康，有性生活，无神经疾病、生殖器或尿道手术史，且未服用任何药物。受试者接受超声、尿流率和残余尿（PVR）测量。所有受试者在研究期间每天进行尿流率测量，随访 22 天（T），并被指示仅在研究期间的特定日期（0、6 和 22）射精。在 0、6 和 22 天，在射精后 2 至 6 小时进行尿流测量。比较射精前后和禁欲期间的尿流率参数。数据呈非正态分布，采用非参数 Wilcoxon 匹配配对检验和 Kruskal-Wallis 检验进行统计学分析。
18 名受试者（平均年龄 27.4 岁）完成了研究。共收集了 414 份尿流图表。射精后 Qmax 显著增加（T-1 Qmax：22.7±5.4 与 T0 Qmax：25.7±8，P=0.002；T5 Qmax 23.2±5.4 与 T6 Qmax 25.4±8，P=0.031；T21 Qmax 21±4.8 与 T22 Qmax 24.5±7.9，P=0.031）。性禁欲导致 Qmax 率呈渐进性、统计学显著下降（T0 Qmax 25.7±8 与 T5 23.2±5.4，P=0.035；T6 Qmax 25.4±8 与 T21 Qmax 21±4.8，P=0.01）。研究期间 PVR 无变化。
我们的结果表明，在年轻健康男性中，排尿可能受射精影响。如果在更大系列的 LUTS 患者中得到证实，我们的发现应该支持性状态和活动可能是尿流率图解释的一个重要混杂因素。
