Green E J, McNaughton B L, Barnes C A
Department of Psychology, University of Colorado, Boulder.
Brain Res. 1990 Oct 8;529(1-2):102-8. doi: 10.1016/0006-8993(90)90816-t.
Animals transferred from their home cages to a different environment exhibited an increase in exploratory behavior which was accompanied by a substantial increase in perforant path-evoked population excitatory postsynaptic potentials and decreases in both the areas and the onset latencies of population spikes. As reported previously, these changes substantially outlasted the exploratory behaviors that induced them. Electrolytic lesions of the medial septum severely attenuated the theta rhythm of the hippocampal EEG, but had no significant effect on the exploration related changes in the synaptic and postsynaptic components of the evoked response. In urethane-anesthetized animals, long trains of hippocampal theta produced by sensory stimulation failed to affect the amplitude of evoked responses. These results show that the information critical for the exploration-related alterations in dentate evoked responses does not originate in or pass through the medial septum, and that the changes are not linked to hippocampal EEG states.
从其饲养笼转移到不同环境中的动物表现出探索行为增加，同时穿孔通路诱发的群体兴奋性突触后电位大幅增加，群体锋电位的面积和起始潜伏期均减小。如先前报道，这些变化比诱发它们的探索行为持续时间长得多。内侧隔区的电解损伤严重减弱了海马脑电图的θ节律，但对诱发反应的突触和突触后成分中与探索相关的变化没有显著影响。在氨基甲酸乙酯麻醉的动物中，感觉刺激产生的长时间海马θ波未能影响诱发反应的幅度。这些结果表明，齿状回诱发反应中与探索相关改变的关键信息并非起源于内侧隔区或通过内侧隔区传递，并且这些变化与海马脑电图状态无关。
