Ametov A S, Kamynina L L
Ter Arkh. 2011;83(5):76-81.
Inhibitors of intestinal enzymes regulate carbohydrate metabolism reducing glycemic index, glycemic load of food and postprandial glycemia which is a prognostic factor of DM2-related cardiovascular complications and death. This class of drugs was proposed for DM2 treatment in 1970s but still holds perspectives. The article gives a detailed description of the mechanism of action, efficacy and safety of inhibitors of alpha-glucosidase and alpha-amilase in experimental and clinical controlled trials.
肠道酶抑制剂可调节碳水化合物代谢，降低血糖生成指数、食物的血糖负荷以及餐后血糖，而后两者是2型糖尿病相关心血管并发症和死亡的预后因素。这类药物于20世纪70年代被提出用于2型糖尿病的治疗，至今仍具有应用前景。本文详细描述了α-葡萄糖苷酶和α-淀粉酶抑制剂在实验和临床对照试验中的作用机制、疗效和安全性。
