纳米尺度研究血液凝固过程中的蛋白质-膜相互作用。
Nanoscale studies of protein-membrane interactions in blood clotting.
机构信息
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
J Thromb Haemost. 2011 Jul;9 Suppl 1(Suppl 1):162-7. doi: 10.1111/j.1538-7836.2011.04300.x.
Abstract
Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.
摘要
在凝血级联反应的大多数步骤中，凝血蛋白都需要与暴露磷脂酰丝氨酸的膜表面结合。尽管这些蛋白-膜相互作用非常重要，但我们仍然缺乏对凝血蛋白如何与膜相互作用以及膜如何对催化产生深远影响的详细了解。我们的实验室正在使用多学科方法，以原子分辨率探索血液凝固蛋白复合物如何在膜表面组装和发挥作用。
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