Li Wen, Huberman-Shlaes Judah, Tian Bozhi
Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Department of Biology, The University of Chicago, Chicago, Illinois 60637, United States.
Langmuir. 2023 Oct 3;39(39):13759-13769. doi: 10.1021/acs.langmuir.3c01274. Epub 2023 Sep 21.
Colloid-based materials with tunable biophysical and chemical properties have demonstrated significant potential in a wide range of biomedical applications. The ability to manipulate these properties across various size scales, encompassing nano-, micro-, and macrodomains, is essential to enhancing current biomedical technologies and facilitating the development of novel applications. Focusing on material design, we explore various synthetic colloid-based materials at the nano- and microscales and investigate their correlation with biological systems. Furthermore, we examine the utilization of the self-assembly of colloids to construct monolithic and macroscopic materials suitable for biointerfaces. By probing the potential of spatial imaging and localized drug delivery, enhanced functionality, and colloidal manipulation, we highlight emerging opportunities that could significantly advance the field of colloid-based materials in biomedical applications.
具有可调节生物物理和化学性质的基于胶体的材料在广泛的生物医学应用中已显示出巨大潜力。在包括纳米、微米和宏观领域的各种尺寸尺度上操纵这些性质的能力，对于增强当前生物医学技术和促进新型应用的开发至关重要。着眼于材料设计，我们探索了纳米和微米尺度上各种基于合成胶体的材料，并研究它们与生物系统的相关性。此外，我们研究了利用胶体的自组装来构建适用于生物界面的整体和宏观材料。通过探究空间成像和局部药物递送、增强功能以及胶体操纵的潜力，我们突出了一些新兴机会，这些机会可能会显著推动基于胶体的材料在生物医学应用领域的发展。
