de Almeida-Silva I, de Oliveira J A A, Rossato M, Salata F Fiacadori, Hyppolito M A
Department of Speech Therapy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
J Laryngol Otol. 2011 Aug;125(8):786-94. doi: 10.1017/S0022215111000612.
High sodium salicylate doses can cause reversible hearing loss and tinnitus, possibly due to reduced outer hair cell electromotility. Sodium salicylate is known to alter outer hair cell structure and function. This study determined the reversibility and cochlear recovery time after administration of an ototoxic sodium salicylate dose to guinea pigs with normal cochlear function.
Prospective experimental investigation.
All animals received a single 500 mg sodium salicylate dose, but with different durations of action. Function was evaluated before drug administration and immediately before sacrifice. Cochleae were processed and viewed using scanning electron microscopy.
Changes in outer hair cell function were observed to be present 2 hours after drug administration, with recovery of normal anatomy beginning after 24 hours. Subsequently, derangement and distortion of cilia reduced, with effects predominantly in row three. At 168 hours, cilia were near-normal but with mild distortions which interfered with normal cochlear physiology.
Ciliary changes persisted for up to 168 hours after ototoxic sodium salicylate administration.
高剂量水杨酸钠可导致可逆性听力损失和耳鸣，可能是由于外毛细胞电运动性降低所致。已知水杨酸钠会改变外毛细胞的结构和功能。本研究确定了对具有正常耳蜗功能的豚鼠给予耳毒性水杨酸钠剂量后其可逆性及耳蜗恢复时间。
前瞻性实验研究。
所有动物均接受单次500毫克水杨酸钠剂量，但作用持续时间不同。在给药前及处死前即刻评估功能。对耳蜗进行处理并使用扫描电子显微镜观察。
给药后2小时观察到外毛细胞功能改变，24小时后开始恢复正常解剖结构。随后，纤毛的紊乱和扭曲减少，主要影响第三排。在168小时时，纤毛接近正常，但有轻微扭曲，干扰了正常的耳蜗生理功能。
耳毒性水杨酸钠给药后，纤毛变化持续长达168小时。
