Srinivasan A, Lavanya R, Sankar J
Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, CHILDS Trust Medical Research Foundation, Chennai, India.
Ann Trop Paediatr. 2011;31(3):273-7. doi: 10.1179/1465328111Y.0000000027.
Hypereosinophilic syndrome in children is rare and is characterised by sustained over-production of eosinophils. An 11-year-old boy was diagnosed with hypereosinophilic syndrome as per standard criteria. He was treated initially with intravenous methylprednisolone, followed by oral prednisolone, to which he showed a limited response. The highest absolute eosinophil count was 27.0×10(9)/L. He was commenced on imatinib mesylate but, because of no response, he was switched to hydroxyurea combined with low-dose prednisolone to which he showed improvement with decreasing levels of eosinophils.
儿童嗜酸性粒细胞增多综合征较为罕见，其特征是嗜酸性粒细胞持续过度生成。一名11岁男孩根据标准诊断为嗜酸性粒细胞增多综合征。他最初接受静脉注射甲泼尼龙治疗，随后口服泼尼松龙，但反应有限。最高绝对嗜酸性粒细胞计数为27.0×10⁹/L。他开始使用甲磺酸伊马替尼治疗，但由于无反应，转而使用羟基脲联合小剂量泼尼松龙治疗，嗜酸性粒细胞水平下降，病情有所改善。
