Northwestern University Medical Center, Chicago, IL, USA.
Dermatitis. 2011 Jul-Aug;22(4):189-92.
Finding alternative hair dyes for individuals allergic to para-phenylenediamine (PPD) has been difficult. Newer permanent and demipermanent hair dyes that have replaced PPD with para-toluenediamine sulfate (PTDS) are now available.
We examined whether individuals allergic to PPD will tolerate PPD-free hair dyes containing PTDS.
A retrospective analysis of patch-test results since October 2006 was done and yielded 28 patients allergic to PPD who were also tested with a hair dye series. From January 2004 through October 2006, seven additional patients allergic to PPD were tested with PTDS but not the full dye series. Patch-test results were analyzed. The newer PTDS dyes were recommended for all PPD-positive PTDS-negative subjects starting in 2008, and these subjects were contacted to determine whether they tolerated the recommended hair-dye products.
Of 28 PPD-allergic patients seen since October 2006, 16 (57.1%) tested negative to all other substances on the dye series. Eleven tested positive to PTDS; of these, several were also allergic to other substances in the hair dye series. There was only one patient who was allergic to ortho-nitro-PPD and not to PTDS. Of 7 additional PPD-allergic patients seen from 2004 through 2006, 4 (57.1%) tested negative to PTDS. In total, 20 of 35 individuals (57.1%) tested positive to PPD but negative to PTDS. Ten of 13 PPD-positive patients for whom PTDS hair dyes were recommended subsequently used a PTDS hair dye, and all tolerated these products.
Fifty-seven percent of patients allergic to PPD in this study will likely tolerate newer permanent and demipermanent hair dyes based on PTDS. Most individuals not allergic to PTDS will also test negative to other substances in the dye series. All 10 patients who tested positive to PPD and negative to PTDS who subsequently used a PTDS dye free of PPD tolerated these products. Many individuals allergic to PPD will benefit from the newer PTDS-based products.
寻找替代对苯二胺（PPD）过敏个体的染发剂一直很困难。现已推出用对甲苯二胺硫酸盐（PTDS）替代 PPD 的新型永久性和半永久性染发剂。
我们研究了对 PPD 过敏的个体是否能耐受不含 PPD 的含 PTDS 的染发剂。
对 2006 年 10 月以来的斑贴试验结果进行回顾性分析，共纳入 28 例对 PPD 过敏的患者，这些患者还接受了染发剂系列测试。2004 年 1 月至 2006 年 10 月，另外 7 例对 PPD 过敏的患者接受了 PTDS 斑贴试验，但未接受全套染发剂测试。分析斑贴试验结果。从 2008 年开始，向所有 PPD 阳性 PTDS 阴性的受试者推荐使用新型 PTDS 染发剂，并与这些受试者联系以确定他们是否耐受推荐的染发剂产品。
2006 年 10 月以来，28 例 PPD 过敏患者中，16 例（57.1%）对染发剂系列中所有其他物质均呈阴性反应。11 例对 PTDS 呈阳性反应；其中一些患者对染发剂系列中的其他物质也过敏。仅有 1 例患者对邻硝基 PPD 过敏，而不对 PTDS 过敏。2004 年至 2006 年期间，另外 7 例 PPD 过敏患者中，4 例（57.1%）对 PTDS 呈阴性反应。总的来说，35 例 PPD 阳性患者中有 20 例（57.1%）对 PPD 呈阳性反应，对 PTDS 呈阴性反应。13 例推荐使用 PTDS 染发剂的 PPD 阳性患者中，有 10 例随后使用了 PTDS 染发剂，并且均耐受这些产品。
本研究中，57%对 PPD 过敏的患者可能耐受基于 PTDS 的新型永久性和半永久性染发剂。大多数不对 PTDS 过敏的个体对染发剂系列中的其他物质也呈阴性反应。所有 10 例 PPD 阳性、PTDS 阴性并随后使用不含 PPD 的 PTDS 染发剂的患者均耐受这些产品。许多对 PPD 过敏的患者将受益于新型 PTDS 产品。
