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人类肺功能对臭氧暴露反应的个体差异。

Individual variability in human lung function responses to ozone exposure.

出版信息

Environ Toxicol Pharmacol. 1996 Oct 15;2(2-3):171-5. doi: 10.1016/S1382-6689(96)00050-6.

DOI:10.1016/S1382-6689(96)00050-6
PMID:21781722
Abstract

Ozone is a common photochemical air pollutant which is present in the ambient air of many urban areas at concentrations sufficient to produce acute respiratory effects in humans. Because individuals vary considerably in the magnitude of their responses to ozone exposure, it is difficult to estimate the number of individuals in a given population who are experiencing adverse effects. Consequently risk and benefits analysis for various regulatory scenarios cannot be carried out with precision. As an aid to risk assessment this paper presents a method of predicting the proportion of individuals in the population who experience a particular health effect. Risk equations predicting the proportion of individuals experiencing lung function decrements as a function of ozone concentration, duration of exposure, and age are presented.

摘要

臭氧是一种常见的光化学空气污染物,存在于许多城市地区的环境空气中,浓度足以对人类产生急性呼吸道影响。由于个体对臭氧暴露的反应程度差异很大,因此很难估计特定人群中出现不良反应的个体数量。因此,对于各种监管情况的风险和效益分析无法精确进行。为了帮助风险评估,本文提出了一种预测人群中出现特定健康影响的个体比例的方法。本文提出了预测个体因臭氧浓度、暴露时间和年龄而导致肺功能下降比例的风险方程。

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Individual variability in human lung function responses to ozone exposure.人类肺功能对臭氧暴露反应的个体差异。
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引用本文的文献

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Innate Lymphoid Cell-Dependent Airway Epithelial and Inflammatory Responses to Inhaled Ozone: A New Paradigm in Pathogenesis.固有淋巴细胞介导的气道上皮对吸入臭氧的炎症反应:发病机制的新范式
Toxicol Pathol. 2019 Dec;47(8):993-1003. doi: 10.1177/0192623319873872. Epub 2019 Sep 19.
2
Evaluating potential response-modifying factors for associations between ozone and health outcomes: a weight-of-evidence approach.评估臭氧与健康结果之间关联的潜在反应修饰因素:一种证据权重法。
Environ Health Perspect. 2014 Nov;122(11):1166-76. doi: 10.1289/ehp.1307541. Epub 2014 Jun 13.
3
Effects of exposure to 0.06 ppm ozone on FEV1 in humans: a secondary analysis of existing data.
暴露于0.06 ppm臭氧对人体第一秒用力呼气容积(FEV1)的影响:现有数据的二次分析
Environ Health Perspect. 2008 Aug;116(8):1023-6. doi: 10.1289/ehp.11396.