Environ Toxicol Pharmacol. 1996 Oct 15;2(2-3):197-9. doi: 10.1016/S1382-6689(96)00055-5.
The application of sparse data analysis techniques, otherwise known as the population approach, to the assessment of pharmacokinetic and pharmacodynamic variability is reviewed. Using software that has recently become available it is now possible to analyse heterogeneous, sparse data from a variety of clinical trials, particularly during drug development. Therefore the pharmacokinetics and pharmacodynamics of a drug can be studied in the target population and this information can be used to guide dosage for optimal therapeutic benefit.
本文回顾了稀疏数据分析技术（也称为群体法）在评估药代动力学和药效学变异性中的应用。最近出现的软件现在可以分析来自各种临床试验的异质稀疏数据，特别是在药物开发期间。因此，可以研究药物在目标人群中的药代动力学和药效学，并且可以使用这些信息来指导剂量以获得最佳治疗效果。
