Pediatric Pneumology and Immunology, Virchow-Hospitals of the Humboldt-University, Augustenburger Platz 1, 13353 Berlin, Germany.
Environ Toxicol Pharmacol. 1997 Nov;4(1-2):79-83. doi: 10.1016/s1382-6689(97)10045-x.
There is epidemiological evidence, especially from longitudinal studies, that clinical manifestations of atopy as well as IgE antibodies against food and aeroallergens show a systematic sequence of events. The atopic march begins with food allergy associated gastrointestinal disorders and atopic dermatitis followed by respiratory allergies, i.e. asthma and atopic rhino-conjunctivitis. Detectable food antibodies, especially against egg and milk proteins, usually precede or accompany the early clinical symptoms and signs. Similarly, aeroallergen sensitization, first against indoor allergen antibodies, succeeded by outdoor allergen antibodies, precede the clinical manifestation of respiratory allergy. Early atopic events, either manifestation or sensitization can be used as risk markers or even predictors of atopic disorders to implement preventive measures. Early atopic dermatitis as well as elevated serum IgE antibodies against food allergens in the first two years of life in combination with a family history can be used as a predictor for aeroallergen sensitization.
有流行病学证据，特别是来自纵向研究的证据表明，特应性的临床表现以及针对食物和空气过敏原的 IgE 抗体显示出一种系统性的事件序列。特应性进程始于与食物过敏相关的胃肠道疾病和特应性皮炎，随后是呼吸道过敏，即哮喘和特应性鼻结膜炎。可检测到的食物抗体，特别是针对鸡蛋和牛奶蛋白的抗体，通常先于或伴随早期临床症状和体征出现。同样，对室内过敏原抗体的空气过敏原致敏，随后是对室外过敏原抗体的致敏，先于呼吸道过敏的临床表现。早期特应性事件，无论是表现还是致敏，都可用作特应性疾病的风险标志物甚至预测指标，以实施预防措施。生命最初两年的早期特应性皮炎以及针对食物过敏原的血清 IgE 抗体升高，同时伴有家族史，可用作空气过敏原致敏的预测指标。
