铀矿石粉尘对人肺细胞的影响。

Effects of uranium ore dust on cultured human lung cells.

机构信息

Second Department of Pathology, Saitama Medical School, Moroyama, Iruma-gun, Saitama, 350-04, Japan.

出版信息

Environ Toxicol Pharmacol. 1998 Jun 2;5(4):267-71. doi: 10.1016/s1382-6689(98)00010-6.

Abstract

Effects of uranium ore dust on cell proliferation, lipid peroxidation and micronuclei formation were compared with silica (DQ12) and titanium oxide in normal human distal airway epithelial cells (NHDE), human lung cancer cells (A549) and human lung fibroblast cells. Cell proliferation was significantly inhibited with uranium ore dust and silica but not with titanium oxide. Lipid peroxidation was significantly enhanced only with uranium ore dust. Micronuclei formation was significantly stimulated with uranium ore dust in A549 and NHDE cells, but not in fibroblast cells. Silica stimulated micronuclei formation only in A549 cells. The results showed the outstanding effect of uranium ore dust on lipid peroxidation and micronuclei formation in human lung cells compared to silica and titanium dioxide.

摘要

铀矿尘对细胞增殖、脂质过氧化和微核形成的影响与二氧化硅（DQ12）和钛氧化物在正常人体远气道上皮细胞（NHDE）、人肺癌细胞（A549）和人肺成纤维细胞中的影响进行了比较。铀矿尘和二氧化硅显著抑制细胞增殖，但钛氧化物则没有。脂质过氧化仅在铀矿尘存在时显著增强。铀矿尘在 A549 和 NHDE 细胞中显著刺激微核形成，但在成纤维细胞中则没有。二氧化硅仅在 A549 细胞中刺激微核形成。结果表明，与二氧化硅和二氧化钛相比，铀矿尘对人肺细胞的脂质过氧化和微核形成具有突出的影响。