由生长激素释放肽和生长激素释放肽受体缺乏小鼠揭示的生理学作用。
Physiological roles revealed by ghrelin and ghrelin receptor deficient mice.
机构信息
Department of Metabolism and Aging, Scripps Research Institute Florida, 130 Scripps Way B3B, Jupiter, FL 33458, United States.
出版信息
Peptides. 2011 Nov;32(11):2229-35. doi: 10.1016/j.peptides.2011.07.003. Epub 2011 Jul 12.
Abstract
Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection. Furthermore, ghrelin could promote overall health and longevity by acting directly in the immune system and promoting an extended antigen repertoire. The development of mice lacking either ghrelin (ghrelin-/-) or its receptor (ghsr-/-) have provided a valuable tool for determining the relevance of ghrelin and its receptor in these multiple and diverse roles. In this review, we summarize the most important findings and lessons learned from the ghrelin-/- and ghsr-/- mice.
摘要
胃饥饿素是一种在胃中产生的激素，主要因其生长激素释放和食欲刺激特性而闻名。然而，胃饥饿素通过其受体 GHS-R1a，已经被证明具有许多作用，包括调节葡萄糖稳态、记忆和学习、食物成瘾和神经保护。此外，胃饥饿素可以通过直接作用于免疫系统并促进扩展的抗原库来促进整体健康和长寿。缺乏胃饥饿素（ghrelin-/-）或其受体（ghsr-/-）的小鼠的发展为确定胃饥饿素及其受体在这些多种和不同作用中的相关性提供了有价值的工具。在这篇综述中，我们总结了从 ghrelin-/- 和 ghsr-/- 小鼠中获得的最重要的发现和经验教训。
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