Institute & Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan.
Neurosci Lett. 2011 Sep 1;501(3):138-42. doi: 10.1016/j.neulet.2011.07.002. Epub 2011 Jul 18.
Although isoflurane, a non-water soluble agent, has been known to block Na+ currents, its spinal anesthetic effect was not exposed. The aim of this experiment was to evaluate the local anesthetic effect of isoflurane in spinal anesthesia. After intrathecal injection of isoflurane on rats, the spinal anesthetic effect in motor function, proprioception and nociception were evaluated. Lidocaine, a common used local anesthetic, was used as control. Isoflurane acted like lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. Although isoflurane [27.6 (25.4-30.0)] had less potency when compared with lidocaine [1.0 (0.9-1.1)] (P<0.001) in spinal anesthesia, it caused a much longer duration of spinal blockades than lidocaine at equianesthetic doses (P<0.001). Our results showed that when compared with lidocaine, isoflurane produced a less potency but much longer duration in spinal anesthesia.
虽然异氟醚是非水溶性药物，已知可阻断 Na+电流，但并未表现出其脊髓麻醉作用。本实验旨在评估异氟醚在脊髓麻醉中的局部麻醉效果。在大鼠鞘内注射异氟醚后，评估其在运动功能、本体感觉和痛觉方面的脊髓麻醉效果。以常用的局部麻醉药利多卡因作为对照。异氟醚的作用类似于利多卡因，可产生剂量相关的运动功能、本体感觉和痛觉的脊髓阻滞。虽然异氟醚[27.6（25.4-30.0）]在脊髓麻醉中的效价低于利多卡因[1.0（0.9-1.1）]（P<0.001），但在等麻醉剂量下，异氟醚引起的脊髓阻滞持续时间比利多卡因长得多（P<0.001）。我们的结果表明，与利多卡因相比，异氟醚在脊髓麻醉中产生的效价较低，但持续时间较长。
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