微阵列技术在套细胞淋巴瘤中的应用。

The use of microarray technologies in mantle cell lymphoma.

机构信息

Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

出版信息

Semin Hematol. 2011 Jul;48(3):166-71. doi: 10.1053/j.seminhematol.2011.03.007.

DOI:10.1053/j.seminhematol.2011.03.007

PMID:21782058

Abstract

Mantle cell lymphoma (MCL) is characterized by adverse prognosis and the development of novel therapeutic approaches is essential to improve outcome. The introduction of gene expression profiling using DNA microarrays has significantly enhanced our understanding of the molecular pathogenesis of MCL, which is a prerequisite to the development of novel treatment strategies. Gene expression profiling can furthermore be applied to predict treatment response at diagnosis and thus can be used to assess a patient's individual risk profile. This review summarizes our current knowledge on the use of microarray technology in MCL.

摘要

套细胞淋巴瘤（MCL）的预后不良，因此开发新的治疗方法对于改善其预后至关重要。应用 DNA 微阵列进行基因表达谱分析显著提高了我们对 MCL 分子发病机制的认识，这是开发新治疗策略的前提。基因表达谱分析还可用于预测诊断时的治疗反应，从而可用于评估患者的个体风险概况。本综述总结了目前在 MCL 中应用微阵列技术的相关知识。